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Laboratory Test Catalog

Synovasure® Comprehensive PJI Panel

Panel Description

The Synovasure® Comprehensive Periprosthetic Joint Infection (PJI) Panel is a comprehensive, synovial fluid test panel to aid in the diagnosis of Periprosthetic Joint Infection (PJI) through the use of multiple biomarkers. Testing using this panel provides sufficient results to fulfill diagnostic criteria from major societies including Musculoskeletal Infection Society (MSIS), International Consensus Meeting (ICM) and European Bone and Joint Infection Society (EBJIS).


Panel Test Components

Synovasure® Alpha Defensin for PJI (Alpha Defensin and C-reactive Protein (CRP))
Synovasure® Microbial Identification (MID)
Synovasure® Neutrophil Elastase (HNE)
Synovial Fluid Culture
White Blood Cell (WBC) Count with Differential
Optional Add-on: Crystal Analysis


Available in New York State?

Yes. A modified version of this panel is available for patients located within New York State. This modified panel includes all tests listed above EXCEPT Synovasure® Microbial Identification.

Specimen Source(s)

Periprosthetic joint prior to implant removal (i.e. Hip or Knee). 

Note: Performance on specimens from other anatomic locations is not defined. Non-intraarticular joint fluid will be tested if Zimmer Biomet is participating in a clinical study.

Specimen Type

Synovial Fluid


Required Volume

6.5 mL (+0.5mL if adding Crystal Analysis test)


Volume by Tube Type*

No Additive Tube 1: 3.0mL

No Additive Tube 2: 3.0mL

EDTA Tube: 0.5mL (+0.5mL if adding Crystal Analysis test)

*Tubes are provided within specimen transportation kits


Specimen Stability

4 days post-aspiration


Ambient/Room Temperature prior to shipment. If being held overnight or over a weekend, store in refrigeration.


Shipping Materials

All materials needed to package and ship are included within transportation kit. Make sure to retain tracking number from provided FedEx label for tracking purposes


Shipping Guidelines

Monday to Friday

Ship specimen the same day as aspiration

Saturday to Sunday

Place in refrigeration and ship specimen on Monday

Specimens are rejected for any of the below reasons:

1.  Specimen is outside stability range (i.e. more than 5 days)

2.  Specimen is not representative of synovial fluid (i.e. blood, urine, etc.)

3.  Specimen is aspirated from a location other than the intra-articular joint space

*Note: Non-synovial fluid or intra-articular joint specimens will be tested if associated with a Zimmer Biomet-approved clinical study.

When submitting a specimen to CD Laboratories for this panel:

    • Do not use lavage, contrast or other foreign liquids to aspirate fluid
    • Ensure specimen is not overly hemolyzed
    • A completed requisition form is required with each specimen
    • A barcode label from the specimen transportation kit is required on the top of completed requisition
    • For Physician Accounts Only: Patient signature and insurance information are required


$259.00 (effective as of 01/01/2023)

+$30.00 if adding Crystal Analysis test

CPT Codes

Test CPT Code
Synovasure® Alpha Defensin for PJI (Alpha Defensin and CRP) Alpha Defensin: 83516
CRP: 86140
Synovasure® Microbial Identification (MID) 87449 (x3)
Synovasure® Neutrophil Elastase (HNE) 83516
Synovial Fluid Culture Aerobic: 87070
Anaerobic : 87075
White Blood Cell (WBC) Count with Differential 89051
Optional Add-on: Crystal Analysis 89060

Product (Kit) SKU



How to Order

Contact your local Zimmer Biomet sales representative to order.

For result or test questions, contact CD Laboratories Customer Service at 888-981-8378 or [email protected]

Download a Sample Report